Journal of Cerebrovascular Disease 2020 Vol.3 No.4 29-37

Progress of Post-traumatic Epilepsy

Author(s): Wei Zhu1,Yuan-Qiang Lu1

Affiliation(s): 1Department of Emergency Medicine, The First Affiliated Hospital, Zhejiang University, School of Medicine

Corresponding Author: Yuan-Qiang Lu

Corresponding email(s):

Key Words: Post-traumatic epilepsy; Traumatic brain injury; Pathophysiology


Post-traumatic epilepsy (PTE) is a serious complication of traumatic brain injury. It is also the most common type of symptomatic epilepsy. This might be associated with the typical pathological changes of brain injury, including reactive glial hyperplasia, axonal retraction ball, Wallerian degeneration, microglial scar formation, and white matter cystic lesions. The prophylactic use of antiepileptic drugs could effectively reduce the risk of early epileptic seizures in patients with severe traumatic brain injury. In this article, we review the epidemiology, pathophysiology, clinical characteristics, and treatment of PTE based on the latest clinical and laboratory research results. 

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On-line Access: 2020-12-01

Received: 2020-09-10

Revision Accepted: 2020-10-29

Publish: 2020-12-01

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