Journal of Cerebrovascular Disease 2018 Vol.1 No.1 1-42

Pupillary Changes after Papaverine Application During Intracranial Aneurysm Surgeries

Author(s): Zhen-Qiang Li1,Cheng-Feng Sun1,Guang-Yao Zhu1,Gang Shen1,Bo-Ding Wang1

Affiliation(s): 1Department of Neurosurgery, Ningbo Medical Center Lihuili Eastern Hospital, Ningbo 315000, China

Corresponding Author: Bo-Ding Wang

Corresponding email(s):

Key Words: Intracranial aneurysm; Papaverine; Intracisternal instillation; Pupillary change


Background: The goal of this paper is to summarize the pupillary changes after papaverine application in intracranial aneurysms surgeries.
Methods: We retrospectively analyzed the clinical data of six intracranial aneurysm patients who were treated with papaverine application during surgery.
Results: Two cases of ipsilateral papillary dilation, two cases of contralateral pupillary dilation, one case of bilateral pupillary dilation, and one case of asymmetric pupils were observed after craniotomy. All of these pupillary changes resolved in one-half to three hours without neurological deficits.
Conclusions: Pupillary changes after the use of papaverine in intracranial aneurysm surgeries may be an instantaneous reaction to papaverine. Most cases can return to normal after close observation.

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On-line Access: 2018-09-01

Received: 2017-11-07

Revision Accepted: 2018-03-01

Publish: 2018-12-01

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